Scientific Program

24th International Conference on Cytochrome P450: Biochemistry, Genomics and Pharmacology

30th June to 4th July, 2025, Bern, Switzerland

Fabrikstrasse 6, 3012 Bern

Scientific program

Day 1, Monday 30.6.2025

Registration Desk open, 9:00 Fabrikstrasse 6

 

Poster mounting, foyer, 9:30 a.m. – 3:30 p.m

 

10:30 – 10:45

Amit V Pandey Opening Remarks

Emily Scott Introduction to the history of the P450 meetings

 

Plenary lecture 1/Waterman Lecture, 10:45–11:45

Chair: Amit Pandey

Walter L. Miller ( UCSF, USA )

Human Disorders of Steroid metabolizing cytochrome P450s.

 

Lunch Fabrikstrasse 8 12:00 – 1:15 pm

 

13:30 to 15:30 Session 1 P450 Pharmacology Chair: Joan Zuo

 

13:30-14:00 Yune-Fang Ueng, Taiwan

The CYP1A2 inhibition by a herbal formula Xin-yi-san: theophylline oxidation and risk assessment.

 

14:00-14:30 Bhagavatula Moorthy, USA

Dual roles of the endogenous Ah receptor (AHR) ligand 6-Formylindolo[3,2-b]carbazole (FICZ) in the induction of pulmonary cytochrome P450 (CYP)1A1 ​​​​induction by hyperoxia, and the attenuation of oxygen-mediated lung injury in mice In Vivo.

 

14:30-15:00 Joan Z Zuo, Hong Kong

CYP450 mediated herb-drug interactions: exemplified by genetic polymorphism based inhibition on CYP450 by Radix Puerariae lobatae in healthy subjects

 

15:00-15:30 Albert Braeuning, Germany

Inhibition of cytochrome P450-dependent xenobiotic metabolism by NF-κB activation and subsequent JAK/STAT activation by the marine biotoxin okadaic acid

13:30 to 15:30 Session 2 Structure of P450 and non-heme oxygenases. Chair: Emily Scott and Shingo Nagano

 

1:30-14:00 Thomas Pochapsky, USA

What NMR teaches us about P450 structure, dynamics and function

 

14:00-14:30 Emily Scott, USA

Cytochrome P450 7B1 structure and analysis of mutations causing disease

 

14:30-15:00 Stephen, Bell, Australia

Engineering efficient peroxygenase activity into cytochrome P450 enzymes for selective CH bond hydroxylations

 

15:00-15:30 Shingo Nagano, Japan

Structure and Mechanism of Plant 2-Oxoglutarate-Dependent Dioxygenases Catalyzing α-Tomatine Oxidation.

 

 

 

Get together (Fabrikstrasse 8), and poster viewing (upper foyer Fabrikstrasse 6), 3:30 pm – 6:00 pm

Day 2 Tuesday, July 1, 2025

Registration Desk Open: 9:00

 

9:00 – 10:00 AM: Plenary Lecture 2: Xinxin Ding, Drug and steroid metabolism using animal model systems.

Chair: Vlada Urlacher

10:00 to 11:30 Session 3 P450 Bioinformatics and Evolution

Chair: David Nelson

 

10:00-10:30 Chris Oostenbrink, Austria

Biomolecular simulations of Cytochrome P450 enzymes

 

10:30-11:00 Martha S Smit, South Africa

Insights into the structural diversity of the cytochrome P450s

 

11:00-11:15 Dominik Gront Poland (short talk)

Integrating structural data to enhance CYP annotation in the P450Atlas

 

11:15-11:30 David Nelson, USA (Short Talk)

Defining the worldwide diversity of cytochrome P450s

 

10:00 to 11:30 Session 4 P450 Biophysics

Chair: Gianfranco Gilardi

 

10:00-10:30 Rams Ramamoorthy, USA

Direct Isolation and Reconstitution of Cytochrome Proteins in Polymer-Based Nanodiscs

 

10:30-11:00 Ilia Denisov, USA

Hydroxylation and lyase reaction mechanisms in CYP17A1

 

11:00-11:30 Nikos Hatzakis, Denmark

Biased P450 activation by controlling P450 oxidoreductase conformational sampling: A single molecule and machine learning perspective

Morning Tea 11:30 to 12:00

 

12:00 to 13:00 Session 3 P450 Bioinformatics and Evolution

 

 

12:10-12:15 Nevin Gül Karagüler, (short talk)

Exploring novel P450 enzymes & redox partners from extremophilic regions by a metagenomic approach

 

12:15-12:30 Facundo Andrés Ortega, (short talk)

 

Two cytochrome P450 enzymes found in the resin acid-degrading bacterium Pseudomonas abieticivorans

 

12:30-1:00 Elizabeth MJ Gillam, Australia

Tracing evolutionary pathways of P450s using ancestral sequence reconstruction

 

 

 

12:00 to 13:00 Session 4 P450 Biophysics

 

12:00 -12:30 Rebecca Wade, Germany

Focusing the computational microscope on the dynamics of mammalian cytochrome P450s and their redox partners

 

12:30-12:45 Yi Chien Tang

Elucidating Biochemistry of Cytochrome P450 2U1 with respect to Lipid and Xenobiotic Metabolism

 

12:45-13:00 Eugen Hruška, Czech Republic (short talk)

Docking predictivity determinants for the P450 flexible active site

 

 

 

Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm

 

 

 

14:00 to 16:00 Session 5 P450 Protein Interactions Chairs: Wayne Backes and Dmitri Davydov

 

14:00-14:30 Wayne Backes, USA

Cytochrome P450 CYP2D6 and heme oxygenase-1 exist as a complex that affects both CYP2D6 and HO-1 function.

 

14:30-15:00 Dmitri Davydov, USA

Functional effects of protein-protein interactions in cytochrome P450 ensemble and their manifestation in the influence of alcohol on drug metabolism

 

15:00-15:30 Sheila Sadeghi, Italy

Tandem reactions of P450s and FMOs in xenobiotic metabolism

 

15:30-16:00 Andrei Gilep, Belarus

Functional interactomics of cytochrome P450s.

14:00 to 16:00 Session 6 Catalytic Mechanisms of Cytochrome P450 Chair: John Hackett

 

14:00-14:30 John Hackett, USA

Applications of small angle scattering to delineate P450-membrane and redox partner interactions.

 

14:30-15:00 James de Voss, Australia

Mechanistic insights from new(ish) radical clock mechanistic probes

 

15:00-15:30 Chul-Ho Yun, South Korea

Cofactor-Free Hydroxylation of Aliphatic C–H bonds by Bacterial Cytochrome P450 and Peroxygenase Enzymes.

 

3:30-4:00 PM Aditi Das, USA

Mechanistic Insights into Cannabinoid Metabolism by Cytochrome P450 Enzymes (Tentative)

 

Afternoon Tea (Fabrikstrasse 6)

16:00 to 18:00 Poster Session 1 Odd numbered Posters (Upper foyer, Fabrikstrasse 6)

 

Day 3 Wednesday, July 2, 2025

Registration Desk Open: 8:30

9:00 – 10:00 AM: Plenary Lecture 3: Vlada Urlacher, Protein engineering of P450 enzymes for sustainable synthesis.

Chair: Birger Moller

10:00 to 12:00

Session 7 P450 Drug Design and targeting

Chair: Irina Pikuleva and Edward T Morgan

 

10:00-10:30 Tomasz Wrobel, Poland

Non-Steroidal Inhibitors of CYP17A1 for Prostate Cancer Therapy

 

10:30-11:00 Irina Pikuleva, USA

CYP46A1 as a Pharmacologic Target for Alzheimer's Disease and Other Brain Disorders

 

11:00-11:15 Jibira Yakubu, Switzerland, (short talk)

Targeting Steroidogenic P450s with Natural Compounds and Nanoparticles for Cancer and Endocrine Disorders

 

11:15-11:30 Hong-Yi Lin (short talk)

Abiraterone-derived dual inhibitor targeting CYP17A1 and HDAC6 as a novel strategy to overcome temozolomide resistance in glioblastoma

 

 

11:30-12:00 Taosheng Chen, USA

Selective chemical inhibition of CYP3A4 and CYP3A5

 

 

10:00 to 12:00

Session 8 Novel P450 Reactions and functions

Chairs: Shengying Li

 

10:00-10:30 Shengying Li, China

New reactions and mechanisms of CYP152 peroxygenases

 

10:30-11:00 Tsung-I-Hsu, Taiwan

Enhancing the efficacy of NK cell therapy against glioblastoma by suppressing CYP17A1 activity

 

11:00-11:30 Binghe Wang

P450 Inhibition and Carbon Monoxide: Possible Pharmacological Implications

 

 11:30 -11:45 Hae Chan Jeong (short talk)

Hydroxylation and epoxidation of terpenoid alcohols by engineered bacterial cytochrome P450

 

11:45-12:00 Ngoc Tan Cao (short talk)

Major factors influencing C–H bond hydroxylation reaction of branched alkanes by bacterial CYP102A1 enzymes

 

Lunch at Fabrikstrasse 8, 12:00 to 2:00 pm

2:30 pm to 5:00 pm Congress Excursion

 

Day 4 Thursday, July 3, 2025

Registration Desk Open: 9:00

9:00 to 10:30

Session 9 Genetics and Genomics of P450 and human diseases

Chair: Rita Bernhardt

 

9:00-9:30 Rachel Tyndale, Canada

The role of polygenic, structurally variable CYP2A6 on Smoking behaviors, Cessation, Brain Imaging and Disease.

 

9:30-10:00 Rita Bernhardt, Germany

Role of cytochromes P450 in the pathogenesis of Parkinson's disease

 

10:00-10:30 Mathias Schwab, Germany

Pharmacogenomics of Cytochrome P450s: From Drug Response Variability to Cancer and Beyond

9:00 to 10:30

Session 10 P450 in Steroid Metabolism

Chairs: Amit Pandey and Toshi Sakaki

 

9:00-9:30 Giovanna di Nardo, Italy

Cytochromes P450 as targets and biocatalysts for detoxification of steroid-mimicking endocrine disruptors.

 

9:30-10:00 Richard Auchus, USA

What happens after electron transfer to human cytochrome P450 17A1?

 

10:00-10:30 Donghak Kim, South Korea

Characterization of CYP19A1 Mutations and Their Influence on Androgen Aromatization and Estrogen Synthesis

 

Morning Tea 10:30 to 11:00

11:00 am to 1:00 pm Session 11 P450 Across Species

Chair: Peter Roy

11:00-11:30 Peter Roy, Canada

A Rash-Inducing Pesticide is Toxified by Skin-Expressed Cytochrome P450s

 

11:30-12:00 Danilo Correddu, Italy

Structural and functional characterization of a novel P450 peroxygenase from the cyanobacterium Rivularia sp. MS3 (CYP152E8)

 

12:00-12:30 Huichang Bi, China

The development of a gut-liver-on-chip model and assessment of the activity of CYP450s in human liver organoids

 

12:30-12:45 Brittany Cooke, Canada, (short talk)

Developing novel pro-insecticides to kill mosquito vectors of disease

 

12:45-13:00 Alecia Rachel Gee, (short talk)

 Assessing the function of a thermophilic CYP152 isolated from a Bacillus species

 

 

11:00 to 13:00 Session 10 P450 in Steroid Metabolism

11:00-11:30 Kaori Yasuda, Japan

Novel Vitamin D Hydroxylation Activity by the CYP3A4 Variant I301T Causing Type 3 Rickets.

 

 

11:30-11:45 Yi-Han Huang (short talk)

Traumatic brain injury ages the metabolic microenvironment and potentially impacts neuronal activity through the cholesterol metabolic enzyme Cyp46a1

 

 

11:45-12:00 Suzanne E. Smit (short talk)

Mapping the metabolism of adrenal 11-oxy androgens in human primary hepatocytes

 

12:00-12:15 Tinkara Kreft

Inducible Cyp51 knockout model revels sterol imbalance and hepatic alterations in adult mouse liver

 

12:15-12:30 Cene Skubic (short talk)

From lanosterol to desmosterol: Sterol-specific modulation of hepatic signaling and gene networks

 

 

12:30-13:00 Amit V Pandey, Bern, Switzerland

Human P450 Redox Partner Variations: Impact on Steroid Metabolism and Disease

 

 

Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm

 

 

14:00 to 16:00 Symposia 11 Session 11 P450 Across Species

Chair: Mark Paine and Jed Goldstone

 

14:00-14:30 Jed Goldstone, USA

 

 

14:30-15:00 Mark Paine, UK

How important are mosquito P450s in the fight against malaria?

 

15:00-15:30 Damjana Rozman, Slovenia

Sterol mediated stress response after diminished CYP51A1

 

15:30-16:00 Toshi Sakaki

Structure-function analysis and practical application of CYP105A1

 

 

14:00 to 16:00 Session 12 Cytochrome P450 Regulation by interacting proteins

Chair: Galina Lepesheva

 

14:00-14:30 Galina Lepesheva, USA

Cryo-EM reveals an ensemble of CPR conformations in solution

 

2:30-3:00 pm Michael Kranendonk, Portugal

Unraveling the molecular complexity of cytochrome P450 oxidoreductase: From enzyme mechanisms to liver disease

 

15:00-15:30 Yuji Ishii, Japan

Maternal TCDD exposure causes growth retardation in rat fetus: Potential involvement of pregnancy-specific TCDD-dependent CYP3A1 induction

 

15:30-15:45 Isabel S. Barata, Switzerland (short talk)

Impact of Val334Ile and Val472Leu variants on cytochrome P450 oxidoreductase activity.

 

15:45-16:00 Huynh Ngoc Dieu Vu (short talk)

First functional expression of a lichen cytochrome P450 enzymes enables in vitro usnic acid biosynthesis

 

16:00 to 18:00 Afternoon Tea and Poster Session 2 Even Number Posters

 

 

19:15 to 22:00 Congress Dinner at Restaurant Tepis Rouge, Gurten Park

 

 

Day 5 Friday, July 4, 2025

Registration Desk Open: 9:00

9:00 - 10:00 AM: Plenary Lecture 4: Birger Lindberg Moller, P450 in Green Biotechnology and sustainable chemistry

Chair:

10:00 to 12:00

Session 13 Regulatory mechanisms of Cytochrome P450

Chair: Petr Pavek

 

10:00-10:30 Petr Pavek, Czech Republic

Pregnane X receptor (PXR) antagonists in the regulation of cytochrome P450 genes

 

10:30-11:00 A Kenneth MacLeod, UK

Humanized mouse models in cytochrome P450 research

 

11:00-11:15 Philipp Ausburger, Switzerland (short talk)

Regulation of adrenal androgen production by thyroid hormones

 

11:15-11:30 Oleksii Skorokhod, Italy (Short Talk)

Post-Translational Modifications of CYP4F11 by 4-Hydroxynonenal: ω-Hydroxylation Impairment and Potential Role in Immunosuppression.

 

11:30-11:45 Przemysław Jan Danek (short talk)

The novel third-generation antipsychotic drug brexpiprazole modulate cytochrome P450 enzymes in the liver.

 

11:45-12:00 Fellanza Halimi (short talk)

Cytochrome P450 activity in sepsis: Insights into gene expression and enzymatic dysfunction

10:00 to 12:00

Session 14 Cytochrome P450 in Drug Metabolism

Chair: Jed Lampe

 

10:00-10:30 Hiroshi Yamazaki, Japan

Drug metabolism and cytochrome P450 across species

 

10:30-11:00 Jed Lampe, USA

Drug Metabolism in the Pathobiome: The Impact of P. aeruginosa Cytochrome P450 Metabolism of Drugs and Endogenous Metabolites.

 

11:00-11:30 Steve Kelley, UK

New antifungal and new understanding of resistance in fungal pathogens.

 

11:30-12:00 Herana Kamal Seneviratne, USA

Understanding CYP450-mediated drug bioactivation in the brain using mass spectrometry imaging.

 

 

 

 

Lunch Fabrikstrasse 8, 12:00 to 13:00

13:00 to 14:30

Session 15 Short Talks by PhD Students

Chair: Jibira Yakubu and Anna Matveeva

13:00-13:15 Kevin D McCarty, USA

Interaction of fatty acid binding protein 1 (FABP1) with cytochromes P450 3A4, 4A11, and 4F11

13:15-13:30 Iiro Aleksi Rautsola, Finland

HLM chip: a microfluidic in vitro model for identifying mechanism-based cytochrome P450 inhibition

13:30-13:45 Francesca Armellino, Italy (short talk)

Characterization of CYP1750B2 from C. tardaugens NBRC 16725 involved in estrogens degradation: possible applications in green wastewater treatment

13:45-14:00 Anna Matveeva, Switzerland (short talk)

CRISPR/Cas9-generated POR knockout cells enable personalized modeling of P450 oxidoreductase deficiency

14:00-14:15 Jonathan Teuffel, Germany (short talk)

Complexation of cytochrome P450 17A1 with its redox proteins in a membrane: Insights from molecular dynamics simulation.

14:15-14:30 Tea Kuvek, Austria (short talk)

Cytochrome P450 classification through dynamic topological binding site description: Linking structure to function

 

13:00 to 14:30

Session 16 Short Talks

Chair: Therina du Toit and Giovanna di Nardo

 

1:00-1:15 pm Catalano, Jaclyn (short talk)

Determining the role of an acidic residue in Cytochrome P450: Insights into the function of CYP2S1

 

13:15-13:30 Lennard Anders (short talk)

Proliferation-Competent Primary-Like Hepatocytes as Platform to Investigate Drug-Drug Interactions and Hepatotoxicity

13:30-13:45 Alexander Wassing (short talk)

P450 library screening for the oxyfunctionalization of N-heterocycles

13:45-14:00 Gianluca Catucci, Italy (short talk)

Terminal hydroxylation of hydrocarbons by CYP153A36 from Acinetobacter radioresistens

14:00-14:15 Yun-Hee Lee (short talk)

Fasting enhances diclofenac hepatotoxicity via the induction of multiple cytochrome p450 enzymes and glutathione depletion in mice

14:15-14:30 Weilong Gu (short talk)

In vitro drug-drug interactions between oxycodone and commonly co-consumed drugs in rat and human liver microsomes

 

14:30 to 15:00 Afternoon Tea

15:00 to 15:45

Plenary Lecture 5: Fred Guengerich

P450, 2025: where are we going?

Chair: Rich Auchus

15:45 to 16:30

Poster Awards,

Introduction to 25th ICCP450 Meeting 2027 in Denver, USA by Jed Lampe

Introduction to 2026 P450 Biodiversity meeting in Woods Hole, USA, by Jed Goldstone

Introduction to MDO 2026 in Hong Kong by Joan Zuo

Closing Remarks: Amit Pandey, Emily Scott