Scientific Program
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24th International Conference on Cytochrome P450: Biochemistry, Genomics and Pharmacology 30th June to 4th July, 2025, Bern, Switzerland Fabrikstrasse 6, 3012 Bern Scientific program Day 1, Monday 30.6.2025 Registration Desk open, 9:00 Fabrikstrasse 6
Poster mounting, foyer, 9:30 a.m. – 3:00 p.m
10:00 – 10:20 Amit V Pandey Opening Remarks Emily Scott Introduction to the history of the P450 meetings
Plenary lecture 1/Waterman Lecture, 10:20–11:10 Chair: Amit Pandey Walter L. Miller ( UCSF, USA ) Human Disorders of Steroid metabolizing cytochrome P450s.
Plenary lecture 2, 11:10-12:00 Chair: Amit Pandey C. Roland Wolf (University of Dundee, UK) Humanized mouse models in cytochrome P450 research
Lunch Fabrikstrasse 8 12:00 – 1:00 pm
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13:30 to 15:30 Session 1 P450 Pharmacology Chair: Joan Zuo Yune-Fang Ueng, Taiwan The CYP1A2 inhibition by a herbal formula Xin-yi-san: theophylline oxidation and risk assessment Bhagwata Moorthy Dual roles of the endogenous Ah receptor (AHR) ligand 6-Formylindolo[3,2-b]carbazole (FICZ) in the induction of pulmonary cytochrome P450 (CYP)1A1 induction by hyperoxia, and the attenuation of oxygen-mediated lung injury in mice In Vivo. Joan Z. Zuo, Hong Kong CYP450 mediated herb-drug interactions: exemplified by genetic polymorphism based inhibition on CYP450 by Radix Puerariae lobatae in healthy subjects Albert Braeuning, Germany Inhibition of cytochrome P450-dependent xenobiotic metabolism by NF-κB activation and subsequent JAK/STAT activation by the marine biotoxin okadaic acid |
13:30 to 15:30 Session 2 P450 and non-heme oxygenase structures Chair: Emily Scott Thomas Pochapsky, USA Understanding Cytochrome P450 Structure and Dynamics using NMR (Tentative) Emily Scott, USA Cytochrome P450 7B1 structure and analysis of mutations causing disease Stephen, Bell, Australia Engineering efficient peroxygenase activity into cytochrome P450 enzymes for selective CH bond hydroxylations Shingo Nagano, Japan |
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Get together and poster viewing, foyer, 3:30 pm – 6:00 pm
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Day 2 Tuesday, July 1, 2025 Registration Desk Open: 9:00
9:00 – 10:00 AM: Plenary Lecture 3: Xinxin Ding, Drug and steroid metabolism using animal model systems. Chair: C. Roland Wolf |
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10:00 to 11:30 Session 3 P450 Bioinformatics and Evolution Chair: David Nelson Rebecca Wade, Germany Simulating Membrane-Bound Cytochrome P450s: Conformational Dynamics and Functional Interactions (Tentative) David Nelson, USA Defining the worldwide diversity of cytochrome P450s Martha S. Smit, South Africa Insights into the structural diversity of the cytochrome P450s |
10:00 to 11:30 Session 4 P450 Biophysics Chair: Gianfranco Gilardi Rams Ramamoorthy, USA Direct Isolation and Reconstitution of Cytochrome Proteins in Polymer-Based Nanodiscs Gianfranco Gilardi, Italy Engineered Cytochromes P450: From Biophysical Characterization to Biocatalysis (Tentative) Ilia Denisov, USA Hydroxylation and lyase reaction mechanisms in CYP17A1 |
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Morning Tea 11:30 to 12:00
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12:00 to 13:00 Session 3 P450 Bioinformatics and Evolution Talks from Abstracts Dominik Gront, Poland (short talk) Integrating structural data to enhance CYP annotation in the P450Atlas
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12:00 to 13:00 Session 4 P450 Biophysics Nikos Hatzakis, Denmark Single-Molecule Biophysics Reveals Conformational Dynamics and Biased Metabolism in the P450 System (Tentative) Talks from Abstracts |
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Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm
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14:00 to 15:30 Session 5 P450 Protein Interactions Chairs: Wayne Backes and Dmitri Davydov Wayne Backes, USA Functional Consequences of Cytochrome P450 Complex Formation in Membranes (Tentative) Dmitri Davydov, USA Functional effects of protein-protein interactions in cytochrome P450 ensemble and their manifestation in the influence of alcohol on drug metabolism. Talks from Abstracts
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14:00 to 15:30 Session 6 Catalytic Mechanisms of Cytochrome P450 Chair: John Hackett John Hackett, USA Biophysical Insights into Ligand Binding Mechanisms and Dynamics of Human Cytochromes P450 (Tentative) James de Voss, Australia Mechanistic insights from new(ish) radical clock mechanistic probes Chul-Ho Yun, South Korea Cofactor-Free Hydroxylation of Aliphatic C–H bonds by Bacterial Cytochrome P450 and Peroxygenase Enzymes. |
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15:30 to 16:00 Afternoon Tea
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16:00 to 17:00 Session 5 P450 Protein Interactions Sheila Sadeghi, Italy Tandem reactions of P450s and FMOs in xenobiotic metabolism Talks from abstract |
16:00 to 17:00 Session 6 Catalytic Mechanisms of Cytochrome P450 Aditi Das, USA Mechanistic Insights into Cannabinoid Metabolism by Cytochrome P450 Enzymes (Tentative) Talks from abstract |
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17:00 to 19:00 Poster Session 1 Odd numbered posters |
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Day 3 Wednesday, July 2, 2025 Registration Desk Open: 8:30 9:00 – 10:00 AM: Plenary Lecture 4: Vlada Urlacher, P450 reactions in Biotechnology applications Chair: Birger Moller |
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10:00 to 12:00 Session 7 P450 Drug Design and targeting Chair: Irina Pikuleva Tomasz Wrobel, Poland Design and Evaluation of Novel Non-Steroidal CYP17A1 Inhibitors for Prostate Cancer Therapy (Tentative) Irina Pikuleva, USA CYP46A1 as a Pharmacologic Target for Alzheimer's Disease and Other Brain Disorders Jibira Yakubu, Switzerland Targeting Steroidogenic P450s with Natural Compounds and Nanoparticles for Cancer and Endocrine Disorders (Tentative) Talks from abstracts
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10:00 to 12:00 Session 8 Novel P450 Reactions and functions Chairs: Soren Bak and Andrei Gilep Soren Bak, Denmark Tsung-I-Hsu, Taiwan Enhancing the efficacy of NK cell therapy against glioblastoma by suppressing CYP17A1 activity Andrei Gilep, Belarus Structure, Function, and Bioelectrochemistry of Steroidogenic and Microbial Cytochrome P450 Systems (Tentative) Shenying Li, China New reactions and mechanisms of CYP152 peroxygenases |
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Lunch at Fabrikstrasse 8, 12:00 to 2:00 pm |
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2:30 pm to 5:00 pm Congress Excursion |
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Day 4 Thursday, July 3, 2025 Registration Desk Open: 9:00 |
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9:00 to 10:30 Session 9 Genetics and Genomics of P450 and human diseases Chair: Rita Bernhardt Rachel Tyndale, Canada Pharmacogenetics of Brain Cytochrome P450s: Implications for Drug Dependence and Personalized Medicine (Tentative) Rita Bernhardt, Germany Role of cytochromes P450 in the pathogenesis of Parkinson's disease Mathias Schwab, Germany Pharmacogenomics of Cytochrome P450s: From Drug Response Variability to Cancer and Beyond (Tentative) |
9:00 to 10:30 Session 10 P450 in Steroid Metabolism Chairs: Amit Pandey and Toshi Sakaki Giovanna di Nardo, Italy Cytochromes P450 as targets and biocatalysts for detoxification of steroid-mimicking endocrine disruptors. Richard Auchus, USA Mechanisms and Kinetics of Complex Steroid Oxidations by Cytochrome P450 Enzymes (Tentative) Donghak Kim, South Korea Characterization of CYP19A1 Mutations and Their Influence on Androgen Aromatization and Estrogen Synthesis |
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Morning Tea 10:30 to 11:00 |
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11:00 am to 1:00 pm Session 11 P450 Across Species Chair: Peter Roy Peter Roy, Canada A Rash-Inducing Pesticide is Toxified by Skin-Expressed Cytochrome P450s Talks from Abstracts |
11:00 to 13:00 Session 10 P450 in Steroid Metabolism Therina du Toit, Switzerland Linking hepatic cytochrome P450 activity to 11Oxy-androgen excess in the fetal-placental unit Kaori Yasuda, Japan Novel Vitamin D Hydroxylation Activity by the CYP3A4 Variant I301T Causing Type 3 Rickets. Amit V Pandey, Bern, Switzerland Human P450 Redox Partner Variations: Impact on Steroid Metabolism and Disease |
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Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm
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14:00 to 16:00 Session 11 P450 Across Species Chair: Mark Paine and Jed Goldstone Jed Goldstone, USA Mark Paine, UK How important are mosquito P450s in the fight against malaria? Damjana Rojman, Slovenia Sterol mediated stress response after diminished CYP51A1 Toshi Sakaki Structure-function analysis and practical application of CYP105A1
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2:00 pm to 4:00 pm Session 12 P450 Interactions Chair: Galina Lepesheva Galina Lepesheva, USA Cryo-EM reveals an ensemble of CPR conformations in solution Michael Kranendonk, Portugal Unraveling the molecular complexity of cytochrome P450 oxidoreductase: From enzyme mechanisms to liver disease Yuji Ishii, Japan Maternal TCDD exposure causes growth retardation in rat fetus: Potential involvement of pregnancy-specific TCDD-dependent CYP3A1 induction |
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16:00 to 18:00 Afternoon Tea and Poster Session 2 Even Number Posters
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19:15 to 22:00 Congress Dinner at Restaurant Tepis Rouge, Gurten Park
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Day 5 Friday, July 4, 2025 Registration Desk Open: 9:00 9:00 - 10:00 AM: Plenary Lecture 5: Birger Lindberg Moller, P450 in Green Biotechnology and sustainable chemistry Chair: Pandey |
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10:00 to 12:00 Session 13 Regulation of Cytochrome P450 Chair: Petr Pavek Petr Pavek, Czech Republic Pregnane X receptor (PXR) antagonists in the regulation of cytochrome P450 genes Xiaobo Zhong, USA Epigenetic Regulation of Cytochrome P450 Expression by Long Noncoding RNAs and Nuclear Receptors (Tentative) Philipp Ausburger, Switzerland (short talk) Regulation of adrenal androgen production by thyroid hormones Oleksii Skorokhod (Short Talk) Post-Translational Modifications of CYP4F11 by 4-Hydroxynonenal: ω-Hydroxylation Impairment and Potential Role in Immunosuppression. |
10:00 to 12:00 Session 14 Cytochrome P450 in Drug Metabolism Chair: Jed Lamp Hiroshi Yamazaki, Japan Drug metabolism and cytochrome P450 across species Jed Lampe, USA Drug Metabolism in the Pathobiome: The Impact of P. aeruginosa Cytochrome P450 Metabolism of Drugs and Endogenous Metabolites. Steve Kelley, UK Azole antifungal inhibitors of CYP51, resistance issues and the continued success of azoles in managing fungal pathogens in medicine and agriculture
Short talks from abstracts
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Lunch Fabrikstrasse 8, 12:00 to 13:00 |
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13:00 to 14:30 Session 15 Short Talks by PhD Students Chair: Jibira Yakubu and Anna Matveeva Kevin D. McCarty, USA Interaction of fatty acid binding protein 1 (FABP1) with cytochromes P450 3A4, 4A11, and 4F11 Iiro Aleksi Rautsola, Finland HLM chip: a microfluidic in vitro model for identifying mechanism-based cytochrome P450 inhibition Francesca Armellino, Italy Characterization of CYP1750B2 from C. tardaugens NBRC 16725 involved in estrogens degradation: possible applications in green wastewater treatment Anna Matveeva, Switzerland CRISPR/Cas9-generated POR knockout cells enable personalized modeling of P450 oxidoreductase deficiency Jonathan Teuffel, Germany Complexation of cytochrome P450 17A1 with its redox proteins in a membrane: Insights from molecular dynamics simulation. Tea Kuvek, Austria Cytochrome P450 classification through dynamic topological binding site description: Linking structure to function |
13:00 to 14:30 Session 16 Short Talks Chair: Therina du Toit and Giovanna di Nardo
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14:30 to 15:00 Afternoon Tea |
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15:00 to 15:45 Plenary Lecture 6: Fred Guengerich P450, 2025: where are we going? Chair: Rich Auchus |
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15:45 to 16:15 Poster Awards, Introduction to 25 th ICCP450 Meeting by Jed Lamp Introduction to MDO 2026 by Joan Zuo Closing Remarks: Amit Pandey, Emily Scott |
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