24th International Conference on Cytochrome P450: Biochemistry, Genomics and Pharmacology
30th June to 4th July, 2025, Bern, Switzerland
Fabrikstrasse 6, 3012 Bern
Scientific program
Day 1, Monday 30.6.2025
Registration Desk open, 9:00 Fabrikstrasse 6
Poster mounting, foyer, 9:30 a.m. – 3:30 p.m
10:30 – 10:45
Amit V Pandey Opening Remarks
Emily Scott Introduction to the history of the P450 meetings
Plenary lecture 1/Waterman Lecture, 10:45–11:45
Chair: Amit Pandey
Walter L. Miller ( UCSF, USA )
Human Disorders of Steroid metabolizing cytochrome P450s.
Lunch Fabrikstrasse 8 12:00 – 1:15 pm
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13:30 to 15:30 Session 1 P450 Pharmacology Chair: Joan Zuo
13:30-14:00 Yune-Fang Ueng, Taiwan
The CYP1A2 inhibition by a herbal formula Xin-yi-san: theophylline oxidation and risk assessment.
14:00-14:30 Bhagavatula Moorthy, USA
Dual roles of the endogenous Ah receptor (AHR) ligand 6-Formylindolo[3,2-b]carbazole (FICZ) in the induction of pulmonary cytochrome P450 (CYP)1A1 induction by hyperoxia, and the attenuation of oxygen-mediated lung injury in mice In Vivo.
14:30-15:00 Joan Z Zuo, Hong Kong
CYP450 mediated herb-drug interactions: exemplified by genetic polymorphism based inhibition on CYP450 by Radix Puerariae lobatae in healthy subjects
15:00-15:30 Albert Braeuning, Germany
Inhibition of cytochrome P450-dependent xenobiotic metabolism by NF-κB activation and subsequent JAK/STAT activation by the marine biotoxin okadaic acid
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13:30 to 15:30 Session 2 Structure of P450 and non-heme oxygenases. Chair: Emily Scott and Shingo Nagano
1:30-14:00 Thomas Pochapsky, USA
What NMR teaches us about P450 structure, dynamics and function
14:00-14:30 Emily Scott, USA
Cytochrome P450 7B1 structure and analysis of mutations causing disease
14:30-15:00 Stephen, Bell, Australia
Engineering efficient peroxygenase activity into cytochrome P450 enzymes for selective CH bond hydroxylations
15:00-15:30 Shingo Nagano, Japan
Structure and Mechanism of Plant 2-Oxoglutarate-Dependent Dioxygenases Catalyzing α-Tomatine Oxidation.
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Get together (Fabrikstrasse 8), and poster viewing (upper foyer Fabrikstrasse 6), 3:30 pm – 6:00 pm
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Day 2 Tuesday, July 1, 2025
Registration Desk Open: 9:00
9:00 – 10:00 AM: Plenary Lecture 2: Xinxin Ding, Drug and steroid metabolism using animal model systems.
Chair: Vlada Urlacher
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10:00 to 11:30 Session 3 P450 Bioinformatics and Evolution
Chair: David Nelson
10:00-10:30 Chris Oostenbrink, Austria
Biomolecular simulations of Cytochrome P450 enzymes
10:30-11:00 Martha S Smit, South Africa
Insights into the structural diversity of the cytochrome P450s
11:00-11:15 Dominik Gront Poland (short talk)
Integrating structural data to enhance CYP annotation in the P450Atlas
11:15-11:30 David Nelson, USA (Short Talk)
Defining the worldwide diversity of cytochrome P450s
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10:00 to 11:30 Session 4 P450 Biophysics
Chair: Gianfranco Gilardi
10:00-10:30 Rams Ramamoorthy, USA
Direct Isolation and Reconstitution of Cytochrome Proteins in Polymer-Based Nanodiscs
10:30-11:00 Ilia Denisov, USA
Hydroxylation and lyase reaction mechanisms in CYP17A1
11:00-11:30 Nikos Hatzakis, Denmark
Biased P450 activation by controlling P450 oxidoreductase conformational sampling: A single molecule and machine learning perspective
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Morning Tea 11:30 to 12:00
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12:00 to 13:00 Session 3 P450 Bioinformatics and Evolution
12:10-12:15 Nevin Gül Karagüler, (short talk)
Exploring novel P450 enzymes & redox partners from extremophilic regions by a metagenomic approach
12:15-12:30 Facundo Andrés Ortega, (short talk)
Two cytochrome P450 enzymes found in the resin acid-degrading bacterium Pseudomonas abieticivorans
12:30-1:00 Elizabeth MJ Gillam, Australia
Tracing evolutionary pathways of P450s using ancestral sequence reconstruction
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12:00 to 13:00 Session 4 P450 Biophysics
12:00 -12:30 Rebecca Wade, Germany
Focusing the computational microscope on the dynamics of mammalian cytochrome P450s and their redox partners
12:30-12:45 Yi Chien Tang
Elucidating Biochemistry of Cytochrome P450 2U1 with respect to Lipid and Xenobiotic Metabolism
12:45-13:00 Eugen Hruška, Czech Republic (short talk)
Docking predictivity determinants for the P450 flexible active site
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Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm
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14:00 to 16:00 Session 5 P450 Protein Interactions Chairs: Wayne Backes and Dmitri Davydov
14:00-14:30 Wayne Backes, USA
Cytochrome P450 CYP2D6 and heme oxygenase-1 exist as a complex that affects both CYP2D6 and HO-1 function.
14:30-15:00 Dmitri Davydov, USA
Functional effects of protein-protein interactions in cytochrome P450 ensemble and their manifestation in the influence of alcohol on drug metabolism
15:00-15:30 Sheila Sadeghi, Italy
Tandem reactions of P450s and FMOs in xenobiotic metabolism
15:30-16:00 Andrei Gilep, Belarus
Functional interactomics of cytochrome P450s.
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14:00 to 16:00 Session 6 Catalytic Mechanisms of Cytochrome P450 Chair: John Hackett
14:00-14:30 John Hackett, USA
Applications of small angle scattering to delineate P450-membrane and redox partner interactions.
14:30-15:00 James de Voss, Australia
Mechanistic insights from new(ish) radical clock mechanistic probes
15:00-15:30 Chul-Ho Yun, South Korea
Cofactor-Free Hydroxylation of Aliphatic C–H bonds by Bacterial Cytochrome P450 and Peroxygenase Enzymes.
3:30-4:00 PM Aditi Das, USA
Mechanistic Insights into Cannabinoid Metabolism by Cytochrome P450 Enzymes (Tentative)
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Afternoon Tea (Fabrikstrasse 6)
16:00 to 18:00 Poster Session 1 Odd numbered Posters (Upper foyer, Fabrikstrasse 6)
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Day 3 Wednesday, July 2, 2025
Registration Desk Open: 8:30
9:00 – 10:00 AM: Plenary Lecture 3: Vlada Urlacher, Protein engineering of P450 enzymes for sustainable synthesis.
Chair: Birger Moller
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10:00 to 12:00
Session 7 P450 Drug Design and targeting
Chair: Irina Pikuleva and Edward T Morgan
10:00-10:30 Tomasz Wrobel, Poland
Non-Steroidal Inhibitors of CYP17A1 for Prostate Cancer Therapy
10:30-11:00 Irina Pikuleva, USA
CYP46A1 as a Pharmacologic Target for Alzheimer's Disease and Other Brain Disorders
11:00-11:15 Jibira Yakubu, Switzerland, (short talk)
Targeting Steroidogenic P450s with Natural Compounds and Nanoparticles for Cancer and Endocrine Disorders
11:15-11:30 Hong-Yi Lin (short talk)
Abiraterone-derived dual inhibitor targeting CYP17A1 and HDAC6 as a novel strategy to overcome temozolomide resistance in glioblastoma
11:30-12:00 Taosheng Chen, USA
Selective chemical inhibition of CYP3A4 and CYP3A5
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10:00 to 12:00
Session 8 Novel P450 Reactions and functions
Chairs: Shengying Li
10:00-10:30 Shengying Li, China
New reactions and mechanisms of CYP152 peroxygenases
10:30-11:00 Tsung-I-Hsu, Taiwan
Enhancing the efficacy of NK cell therapy against glioblastoma by suppressing CYP17A1 activity
11:00-11:30 Binghe Wang
P450 Inhibition and Carbon Monoxide: Possible Pharmacological Implications
11:30 -11:45 Hae Chan Jeong (short talk)
Hydroxylation and epoxidation of terpenoid alcohols by engineered bacterial cytochrome P450
11:45-12:00 Ngoc Tan Cao (short talk)
Major factors influencing C–H bond hydroxylation reaction of branched alkanes by bacterial CYP102A1 enzymes
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Lunch at Fabrikstrasse 8, 12:00 to 2:00 pm
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2:30 pm to 5:00 pm Congress Excursion
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Day 4 Thursday, July 3, 2025
Registration Desk Open: 9:00
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9:00 to 10:30
Session 9 Genetics and Genomics of P450 and human diseases
Chair: Rita Bernhardt
9:00-9:30 Rachel Tyndale, Canada
The role of polygenic, structurally variable CYP2A6 on Smoking behaviors, Cessation, Brain Imaging and Disease.
9:30-10:00 Rita Bernhardt, Germany
Role of cytochromes P450 in the pathogenesis of Parkinson's disease
10:00-10:30 Mathias Schwab, Germany
Pharmacogenomics of Cytochrome P450s: From Drug Response Variability to Cancer and Beyond
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9:00 to 10:30
Session 10 P450 in Steroid Metabolism
Chairs: Amit Pandey and Toshi Sakaki
9:00-9:30 Giovanna di Nardo, Italy
Cytochromes P450 as targets and biocatalysts for detoxification of steroid-mimicking endocrine disruptors.
9:30-10:00 Richard Auchus, USA
What happens after electron transfer to human cytochrome P450 17A1?
10:00-10:30 Donghak Kim, South Korea
Characterization of CYP19A1 Mutations and Their Influence on Androgen Aromatization and Estrogen Synthesis
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Morning Tea 10:30 to 11:00
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11:00 am to 1:00 pm Session 11 P450 Across Species
Chair: Peter Roy
11:00-11:30 Peter Roy, Canada
A Rash-Inducing Pesticide is Toxified by Skin-Expressed Cytochrome P450s
11:30-12:00 Danilo Correddu, Italy
Structural and functional characterization of a novel P450 peroxygenase from the cyanobacterium Rivularia sp. MS3 (CYP152E8)
12:00-12:30 Huichang Bi, China
The development of a gut-liver-on-chip model and assessment of the activity of CYP450s in human liver organoids
12:30-12:45 Brittany Cooke, Canada, (short talk)
Developing novel pro-insecticides to kill mosquito vectors of disease
12:45-13:00 Alecia Rachel Gee, (short talk)
Assessing the function of a thermophilic CYP152 isolated from a Bacillus species
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11:00 to 13:00 Session 10 P450 in Steroid Metabolism
11:00-11:30 Kaori Yasuda, Japan
Novel Vitamin D Hydroxylation Activity by the CYP3A4 Variant I301T Causing Type 3 Rickets.
11:30-11:45 Yi-Han Huang (short talk)
Traumatic brain injury ages the metabolic microenvironment and potentially impacts neuronal activity through the cholesterol metabolic enzyme Cyp46a1
11:45-12:00 Suzanne E. Smit (short talk)
Mapping the metabolism of adrenal 11-oxy androgens in human primary hepatocytes
12:00-12:15 Tinkara Kreft
Inducible Cyp51 knockout model revels sterol imbalance and hepatic alterations in adult mouse liver
12:15-12:30 Cene Skubic (short talk)
From lanosterol to desmosterol: Sterol-specific modulation of hepatic signaling and gene networks
12:30-13:00 Amit V Pandey, Bern, Switzerland
Human P450 Redox Partner Variations: Impact on Steroid Metabolism and Disease
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Lunch at Fabrikstrasse 8, 1:00 pm to 2:00 pm
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14:00 to 16:00 Symposia 11 Session 11 P450 Across Species
Chair: Mark Paine and Jed Goldstone
14:00-14:30 Jed Goldstone, USA
14:30-15:00 Mark Paine, UK
How important are mosquito P450s in the fight against malaria?
15:00-15:30 Damjana Rozman, Slovenia
Sterol mediated stress response after diminished CYP51A1
15:30-16:00 Toshi Sakaki
Structure-function analysis and practical application of CYP105A1
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14:00 to 16:00 Session 12 Cytochrome P450 Regulation by interacting proteins
Chair: Galina Lepesheva
14:00-14:30 Galina Lepesheva, USA
Cryo-EM reveals an ensemble of CPR conformations in solution
2:30-3:00 pm Michael Kranendonk, Portugal
Unraveling the molecular complexity of cytochrome P450 oxidoreductase: From enzyme mechanisms to liver disease
15:00-15:30 Yuji Ishii, Japan
Maternal TCDD exposure causes growth retardation in rat fetus: Potential involvement of pregnancy-specific TCDD-dependent CYP3A1 induction
15:30-15:45 Isabel S. Barata, Switzerland (short talk)
Impact of Val334Ile and Val472Leu variants on cytochrome P450 oxidoreductase activity.
15:45-16:00 Huynh Ngoc Dieu Vu (short talk)
First functional expression of a lichen cytochrome P450 enzymes enables in vitro usnic acid biosynthesis
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16:00 to 18:00 Afternoon Tea and Poster Session 2 Even Number Posters
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19:15 to 22:00 Congress Dinner at Restaurant Tepis Rouge, Gurten Park
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Day 5 Friday, July 4, 2025
Registration Desk Open: 9:00
9:00 - 10:00 AM: Plenary Lecture 4: Birger Lindberg Moller, P450 in Green Biotechnology and sustainable chemistry
Chair:
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10:00 to 12:00
Session 13 Regulatory mechanisms of Cytochrome P450
Chair: Petr Pavek
10:00-10:30 Petr Pavek, Czech Republic
Pregnane X receptor (PXR) antagonists in the regulation of cytochrome P450 genes
10:30-11:00 A Kenneth MacLeod, UK
Humanized mouse models in cytochrome P450 research
11:00-11:15 Philipp Ausburger, Switzerland (short talk)
Regulation of adrenal androgen production by thyroid hormones
11:15-11:30 Oleksii Skorokhod, Italy (Short Talk)
Post-Translational Modifications of CYP4F11 by 4-Hydroxynonenal: ω-Hydroxylation Impairment and Potential Role in Immunosuppression.
11:30-11:45 Przemysław Jan Danek (short talk)
The novel third-generation antipsychotic drug brexpiprazole modulate cytochrome P450 enzymes in the liver.
11:45-12:00 Fellanza Halimi (short talk)
Cytochrome P450 activity in sepsis: Insights into gene expression and enzymatic dysfunction
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10:00 to 12:00
Session 14 Cytochrome P450 in Drug Metabolism
Chair: Jed Lampe
10:00-10:30 Hiroshi Yamazaki, Japan
Drug metabolism and cytochrome P450 across species
10:30-11:00 Jed Lampe, USA
Drug Metabolism in the Pathobiome: The Impact of P. aeruginosa Cytochrome P450 Metabolism of Drugs and Endogenous Metabolites.
11:00-11:30 Steve Kelley, UK
New antifungal and new understanding of resistance in fungal pathogens.
11:30-12:00 Herana Kamal Seneviratne, USA
Understanding CYP450-mediated drug bioactivation in the brain using mass spectrometry imaging.
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Lunch Fabrikstrasse 8, 12:00 to 13:00
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13:00 to 14:30
Session 15 Short Talks by PhD Students
Chair: Jibira Yakubu and Anna Matveeva
13:00-13:15 Kevin D McCarty, USA
Interaction of fatty acid binding protein 1 (FABP1) with cytochromes P450 3A4, 4A11, and 4F11
13:15-13:30 Iiro Aleksi Rautsola, Finland
HLM chip: a microfluidic in vitro model for identifying mechanism-based cytochrome P450 inhibition
13:30-13:45 Francesca Armellino, Italy (short talk)
Characterization of CYP1750B2 from C. tardaugens NBRC 16725 involved in estrogens degradation: possible applications in green wastewater treatment
13:45-14:00 Anna Matveeva, Switzerland (short talk)
CRISPR/Cas9-generated POR knockout cells enable personalized modeling of P450 oxidoreductase deficiency
14:00-14:15 Jonathan Teuffel, Germany (short talk)
Complexation of cytochrome P450 17A1 with its redox proteins in a membrane: Insights from molecular dynamics simulation.
14:15-14:30 Tea Kuvek, Austria (short talk)
Cytochrome P450 classification through dynamic topological binding site description: Linking structure to function
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13:00 to 14:30
Session 16 Short Talks
Chair: Therina du Toit and Giovanna di Nardo
1:00-1:15 pm Catalano, Jaclyn (short talk)
Determining the role of an acidic residue in Cytochrome P450: Insights into the function of CYP2S1
13:15-13:30 Lennard Anders (short talk)
Proliferation-Competent Primary-Like Hepatocytes as Platform to Investigate Drug-Drug Interactions and Hepatotoxicity
13:30-13:45 Alexander Wassing (short talk)
P450 library screening for the oxyfunctionalization of N-heterocycles
13:45-14:00 Gianluca Catucci, Italy (short talk)
Terminal hydroxylation of hydrocarbons by CYP153A36 from Acinetobacter radioresistens
14:00-14:15 Yun-Hee Lee (short talk)
Fasting enhances diclofenac hepatotoxicity via the induction of multiple cytochrome p450 enzymes and glutathione depletion in mice
14:15-14:30 Weilong Gu (short talk)
In vitro drug-drug interactions between oxycodone and commonly co-consumed drugs in rat and human liver microsomes
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14:30 to 15:00 Afternoon Tea
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15:00 to 15:45
Plenary Lecture 5: Fred Guengerich
P450, 2025: where are we going?
Chair: Rich Auchus
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15:45 to 16:30
Poster Awards,
Introduction to 25th ICCP450 Meeting 2027 in Denver, USA by Jed Lampe
Introduction to 2026 P450 Biodiversity meeting in Woods Hole, USA, by Jed Goldstone
Introduction to MDO 2026 in Hong Kong by Joan Zuo
Closing Remarks: Amit Pandey, Emily Scott
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